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transgenic hip rats (rip-hat)  (Charles River Laboratories)

 
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    Charles River Laboratories transgenic hip rats (rip-hat)
    Animal studies demonstrated that RA strongly reduced amylin amyloid islet deposition and ameliorated diabetic pathology in <t>transgenic</t> diabetic <t>HIP</t> rats. Prediabetic HIP rats (6-month-old) were treated (HIP+RA) or untreated (HIP) with dietary supplementation of 0.5% (w/w) RA in regular chow diet for 4 months. Age-matched wild-type Sprague–Dawley rats with regular chow diet served as negative controls (WT). At the end of the treatments, rats were euthanized, and pancreatic tissues and sera were collected for immunohistochemistry and biochemical analysis. (A) Representative Congo red staining demonstrated strong amyloid staining in untreated HIP rat pancreatic tissue slices (orange-red color in the islets, middle panel). Congo red staining was significantly reduced in the islets of RA-treated HIP rats with only residue staining remaining (right panel). No Congo red staining was observed in islets in control wild-type SD rats (left panel). All pancreatic islets are marked by red asterisks. These qualitative results represent multiple samples from RA-treated or untreated HIP rats or WT Sprague–Dawley controls (n = 4), and at least 50 islets from pancreatic head, body, and tail for each group were examined. Scale bar in each panel is 100 μm. (B) Representative amylin deposition in the pancreatic tissue slice using amylin antibody staining from different rat groups. Pancreatic tissue slices were stained with amylin-specific antibody (T-4157) followed by secondary antibody and NovaRED substrate (Vector Lab) treatment. Stained islets are shown in dark brown color. Islets in the pancreatic slices from untreated HIP rats were intensely stained, whereas those from RA-treated and control SD rats were only weakly stained. At least 10 tissue slices were observed from each group. Scale bar in each panel as indicated is 1 mm. (C) Serum glucose levels were quantified for each group of rats. Significant reduction of serum glucose concentration was observed, indicated by asterisks (p < 0.05 or p < 0.01) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats. (D) Insulin levels were measured for each group of rats. Statistically lower levels of insulin were observed and indicated by asterisks (p < 0.05) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats (n = 4).
    Transgenic Hip Rats (Rip Hat), supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hip+rats+rip+hat/pmc10074477-256-0-13?v=Charles+River+Laboratories
    Average 90 stars, based on 1 article reviews
    transgenic hip rats (rip-hat) - by Bioz Stars, 2026-07
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    1) Product Images from "Catechol-containing compounds are a broad class of protein aggregation inhibitors: Redox state is a key determinant of the inhibitory activities"

    Article Title: Catechol-containing compounds are a broad class of protein aggregation inhibitors: Redox state is a key determinant of the inhibitory activities

    Journal: Pharmacological research

    doi: 10.1016/j.phrs.2022.106409

    Animal studies demonstrated that RA strongly reduced amylin amyloid islet deposition and ameliorated diabetic pathology in transgenic diabetic HIP rats. Prediabetic HIP rats (6-month-old) were treated (HIP+RA) or untreated (HIP) with dietary supplementation of 0.5% (w/w) RA in regular chow diet for 4 months. Age-matched wild-type Sprague–Dawley rats with regular chow diet served as negative controls (WT). At the end of the treatments, rats were euthanized, and pancreatic tissues and sera were collected for immunohistochemistry and biochemical analysis. (A) Representative Congo red staining demonstrated strong amyloid staining in untreated HIP rat pancreatic tissue slices (orange-red color in the islets, middle panel). Congo red staining was significantly reduced in the islets of RA-treated HIP rats with only residue staining remaining (right panel). No Congo red staining was observed in islets in control wild-type SD rats (left panel). All pancreatic islets are marked by red asterisks. These qualitative results represent multiple samples from RA-treated or untreated HIP rats or WT Sprague–Dawley controls (n = 4), and at least 50 islets from pancreatic head, body, and tail for each group were examined. Scale bar in each panel is 100 μm. (B) Representative amylin deposition in the pancreatic tissue slice using amylin antibody staining from different rat groups. Pancreatic tissue slices were stained with amylin-specific antibody (T-4157) followed by secondary antibody and NovaRED substrate (Vector Lab) treatment. Stained islets are shown in dark brown color. Islets in the pancreatic slices from untreated HIP rats were intensely stained, whereas those from RA-treated and control SD rats were only weakly stained. At least 10 tissue slices were observed from each group. Scale bar in each panel as indicated is 1 mm. (C) Serum glucose levels were quantified for each group of rats. Significant reduction of serum glucose concentration was observed, indicated by asterisks (p < 0.05 or p < 0.01) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats. (D) Insulin levels were measured for each group of rats. Statistically lower levels of insulin were observed and indicated by asterisks (p < 0.05) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats (n = 4).
    Figure Legend Snippet: Animal studies demonstrated that RA strongly reduced amylin amyloid islet deposition and ameliorated diabetic pathology in transgenic diabetic HIP rats. Prediabetic HIP rats (6-month-old) were treated (HIP+RA) or untreated (HIP) with dietary supplementation of 0.5% (w/w) RA in regular chow diet for 4 months. Age-matched wild-type Sprague–Dawley rats with regular chow diet served as negative controls (WT). At the end of the treatments, rats were euthanized, and pancreatic tissues and sera were collected for immunohistochemistry and biochemical analysis. (A) Representative Congo red staining demonstrated strong amyloid staining in untreated HIP rat pancreatic tissue slices (orange-red color in the islets, middle panel). Congo red staining was significantly reduced in the islets of RA-treated HIP rats with only residue staining remaining (right panel). No Congo red staining was observed in islets in control wild-type SD rats (left panel). All pancreatic islets are marked by red asterisks. These qualitative results represent multiple samples from RA-treated or untreated HIP rats or WT Sprague–Dawley controls (n = 4), and at least 50 islets from pancreatic head, body, and tail for each group were examined. Scale bar in each panel is 100 μm. (B) Representative amylin deposition in the pancreatic tissue slice using amylin antibody staining from different rat groups. Pancreatic tissue slices were stained with amylin-specific antibody (T-4157) followed by secondary antibody and NovaRED substrate (Vector Lab) treatment. Stained islets are shown in dark brown color. Islets in the pancreatic slices from untreated HIP rats were intensely stained, whereas those from RA-treated and control SD rats were only weakly stained. At least 10 tissue slices were observed from each group. Scale bar in each panel as indicated is 1 mm. (C) Serum glucose levels were quantified for each group of rats. Significant reduction of serum glucose concentration was observed, indicated by asterisks (p < 0.05 or p < 0.01) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats. (D) Insulin levels were measured for each group of rats. Statistically lower levels of insulin were observed and indicated by asterisks (p < 0.05) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats (n = 4).

    Techniques Used: Transgenic Assay, Immunohistochemistry, Staining, Residue, Control, Plasmid Preparation, Concentration Assay



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    transgenic hip rats (rip-hat)  (Charles River Laboratories)
    90
    Charles River Laboratories transgenic hip rats (rip-hat)
    Animal studies demonstrated that RA strongly reduced amylin amyloid islet deposition and ameliorated diabetic pathology in <t>transgenic</t> diabetic <t>HIP</t> rats. Prediabetic HIP rats (6-month-old) were treated (HIP+RA) or untreated (HIP) with dietary supplementation of 0.5% (w/w) RA in regular chow diet for 4 months. Age-matched wild-type Sprague–Dawley rats with regular chow diet served as negative controls (WT). At the end of the treatments, rats were euthanized, and pancreatic tissues and sera were collected for immunohistochemistry and biochemical analysis. (A) Representative Congo red staining demonstrated strong amyloid staining in untreated HIP rat pancreatic tissue slices (orange-red color in the islets, middle panel). Congo red staining was significantly reduced in the islets of RA-treated HIP rats with only residue staining remaining (right panel). No Congo red staining was observed in islets in control wild-type SD rats (left panel). All pancreatic islets are marked by red asterisks. These qualitative results represent multiple samples from RA-treated or untreated HIP rats or WT Sprague–Dawley controls (n = 4), and at least 50 islets from pancreatic head, body, and tail for each group were examined. Scale bar in each panel is 100 μm. (B) Representative amylin deposition in the pancreatic tissue slice using amylin antibody staining from different rat groups. Pancreatic tissue slices were stained with amylin-specific antibody (T-4157) followed by secondary antibody and NovaRED substrate (Vector Lab) treatment. Stained islets are shown in dark brown color. Islets in the pancreatic slices from untreated HIP rats were intensely stained, whereas those from RA-treated and control SD rats were only weakly stained. At least 10 tissue slices were observed from each group. Scale bar in each panel as indicated is 1 mm. (C) Serum glucose levels were quantified for each group of rats. Significant reduction of serum glucose concentration was observed, indicated by asterisks (p < 0.05 or p < 0.01) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats. (D) Insulin levels were measured for each group of rats. Statistically lower levels of insulin were observed and indicated by asterisks (p < 0.05) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats (n = 4).
    Transgenic Hip Rats (Rip Hat), supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hip+rats+rip+hat/pmc10074477-256-0-13?v=Charles+River+Laboratories
    Average 90 stars, based on 1 article reviews
    transgenic hip rats (rip-hat) - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    hip rats rip hat  (Charles River Laboratories)
    86
    Charles River Laboratories hip rats rip hat
    Animal studies demonstrated that RA strongly reduced amylin amyloid islet deposition and ameliorated diabetic pathology in <t>transgenic</t> diabetic <t>HIP</t> rats. Prediabetic HIP rats (6-month-old) were treated (HIP+RA) or untreated (HIP) with dietary supplementation of 0.5% (w/w) RA in regular chow diet for 4 months. Age-matched wild-type Sprague–Dawley rats with regular chow diet served as negative controls (WT). At the end of the treatments, rats were euthanized, and pancreatic tissues and sera were collected for immunohistochemistry and biochemical analysis. (A) Representative Congo red staining demonstrated strong amyloid staining in untreated HIP rat pancreatic tissue slices (orange-red color in the islets, middle panel). Congo red staining was significantly reduced in the islets of RA-treated HIP rats with only residue staining remaining (right panel). No Congo red staining was observed in islets in control wild-type SD rats (left panel). All pancreatic islets are marked by red asterisks. These qualitative results represent multiple samples from RA-treated or untreated HIP rats or WT Sprague–Dawley controls (n = 4), and at least 50 islets from pancreatic head, body, and tail for each group were examined. Scale bar in each panel is 100 μm. (B) Representative amylin deposition in the pancreatic tissue slice using amylin antibody staining from different rat groups. Pancreatic tissue slices were stained with amylin-specific antibody (T-4157) followed by secondary antibody and NovaRED substrate (Vector Lab) treatment. Stained islets are shown in dark brown color. Islets in the pancreatic slices from untreated HIP rats were intensely stained, whereas those from RA-treated and control SD rats were only weakly stained. At least 10 tissue slices were observed from each group. Scale bar in each panel as indicated is 1 mm. (C) Serum glucose levels were quantified for each group of rats. Significant reduction of serum glucose concentration was observed, indicated by asterisks (p < 0.05 or p < 0.01) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats. (D) Insulin levels were measured for each group of rats. Statistically lower levels of insulin were observed and indicated by asterisks (p < 0.05) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats (n = 4).
    Hip Rats Rip Hat, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/hip+rats+rip+hat/pm34423269-103-0-12?v=Charles+River+Laboratories
    Average 86 stars, based on 1 article reviews
    hip rats rip hat - by Bioz Stars, 2026-07
    86/100 stars
    		  Buy from Supplier

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    Animal studies demonstrated that RA strongly reduced amylin amyloid islet deposition and ameliorated diabetic pathology in transgenic diabetic HIP rats. Prediabetic HIP rats (6-month-old) were treated (HIP+RA) or untreated (HIP) with dietary supplementation of 0.5% (w/w) RA in regular chow diet for 4 months. Age-matched wild-type Sprague–Dawley rats with regular chow diet served as negative controls (WT). At the end of the treatments, rats were euthanized, and pancreatic tissues and sera were collected for immunohistochemistry and biochemical analysis. (A) Representative Congo red staining demonstrated strong amyloid staining in untreated HIP rat pancreatic tissue slices (orange-red color in the islets, middle panel). Congo red staining was significantly reduced in the islets of RA-treated HIP rats with only residue staining remaining (right panel). No Congo red staining was observed in islets in control wild-type SD rats (left panel). All pancreatic islets are marked by red asterisks. These qualitative results represent multiple samples from RA-treated or untreated HIP rats or WT Sprague–Dawley controls (n = 4), and at least 50 islets from pancreatic head, body, and tail for each group were examined. Scale bar in each panel is 100 μm. (B) Representative amylin deposition in the pancreatic tissue slice using amylin antibody staining from different rat groups. Pancreatic tissue slices were stained with amylin-specific antibody (T-4157) followed by secondary antibody and NovaRED substrate (Vector Lab) treatment. Stained islets are shown in dark brown color. Islets in the pancreatic slices from untreated HIP rats were intensely stained, whereas those from RA-treated and control SD rats were only weakly stained. At least 10 tissue slices were observed from each group. Scale bar in each panel as indicated is 1 mm. (C) Serum glucose levels were quantified for each group of rats. Significant reduction of serum glucose concentration was observed, indicated by asterisks (p < 0.05 or p < 0.01) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats. (D) Insulin levels were measured for each group of rats. Statistically lower levels of insulin were observed and indicated by asterisks (p < 0.05) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats (n = 4).

    Journal: Pharmacological research

    Article Title: Catechol-containing compounds are a broad class of protein aggregation inhibitors: Redox state is a key determinant of the inhibitory activities

    doi: 10.1016/j.phrs.2022.106409

    Figure Lengend Snippet: Animal studies demonstrated that RA strongly reduced amylin amyloid islet deposition and ameliorated diabetic pathology in transgenic diabetic HIP rats. Prediabetic HIP rats (6-month-old) were treated (HIP+RA) or untreated (HIP) with dietary supplementation of 0.5% (w/w) RA in regular chow diet for 4 months. Age-matched wild-type Sprague–Dawley rats with regular chow diet served as negative controls (WT). At the end of the treatments, rats were euthanized, and pancreatic tissues and sera were collected for immunohistochemistry and biochemical analysis. (A) Representative Congo red staining demonstrated strong amyloid staining in untreated HIP rat pancreatic tissue slices (orange-red color in the islets, middle panel). Congo red staining was significantly reduced in the islets of RA-treated HIP rats with only residue staining remaining (right panel). No Congo red staining was observed in islets in control wild-type SD rats (left panel). All pancreatic islets are marked by red asterisks. These qualitative results represent multiple samples from RA-treated or untreated HIP rats or WT Sprague–Dawley controls (n = 4), and at least 50 islets from pancreatic head, body, and tail for each group were examined. Scale bar in each panel is 100 μm. (B) Representative amylin deposition in the pancreatic tissue slice using amylin antibody staining from different rat groups. Pancreatic tissue slices were stained with amylin-specific antibody (T-4157) followed by secondary antibody and NovaRED substrate (Vector Lab) treatment. Stained islets are shown in dark brown color. Islets in the pancreatic slices from untreated HIP rats were intensely stained, whereas those from RA-treated and control SD rats were only weakly stained. At least 10 tissue slices were observed from each group. Scale bar in each panel as indicated is 1 mm. (C) Serum glucose levels were quantified for each group of rats. Significant reduction of serum glucose concentration was observed, indicated by asterisks (p < 0.05 or p < 0.01) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats. (D) Insulin levels were measured for each group of rats. Statistically lower levels of insulin were observed and indicated by asterisks (p < 0.05) comparing the untreated HIP rats with those of RA-treated HIP rats or control SD rats (n = 4).

    Article Snippet: Transgenic HIP rats (RIP-HAT) and wild-type Sprague–Dawley (SD) control rats were purchased from Charles River Laboratories (Wilmington, MA).

    Techniques: Transgenic Assay, Immunohistochemistry, Staining, Residue, Control, Plasmid Preparation, Concentration Assay